Article

A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory…

medRxiv · 2025 · Pons-Grifols, A.; Tarres-Freixas, F.; Perez, M.; Riveira-Munoz, E.; Raich-Regue, D.; Perez-Zsolt, D.; Munoz-Basagoiti, J.; Tondelli, B.; Izquierdo-Useros, N.; Capdevila, S.; Vergara-Alert, J.; Urrea, V.; Carrillo, J.; Ballana, E.; Forrow, S.; Clotet, B.; Segales, J.; Trinite, B.; Blanco, J.

Key facts

Title A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model.
First author Pons-Grifols, A.; Tarres-Freixas, F.; Perez, M.; Riveira-Munoz, E.; Raich-Regue, D.; Perez-Zsolt, D.; Munoz-Basagoiti, J.; Tondelli, B.; Izquierdo-Useros, N.; Capdevila, S.; Vergara-Alert, J.; Urrea, V.; Carrillo, J.; Ballana, E.; Forrow, S.; Clotet, B.; Segales, J.; Trinite, B.; Blanco, J.
Journal medRxiv
Published Jan 1, 2025
DOI 10.1101/2024.06.11.598471
Devices mentioned K073506, K083846, K121399, K140377
Product codes mentioned NSU, NUA, PCH

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  • 1–9 FDA submissions mentioned
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